---
title: "Rosetta"
source: https://www.jemoka.com/posts/kbhrosetta/
---

Rosetta is a set of physical-based protein folding models.
protein binding with Rosetta check a protein surface check how protein side-chains interact with the binding surface peptide binding with Rosetta The difficulty with this is that we don&rsquo;t know what the overall tertiary structure of a group of peptides are; unlike whole protein binding.
sequence-specific DNA binding ???
more! You take something like a trimer; you shove a peptide between each &ldquo;point&rdquo;, and boom structal change to a quadromer
