---
title: "RoseTTAFold2"
type: concept
related: [Rosetta, Rosettafold2]
source: https://www.jemoka.com/posts/kbhrosettafold2/
confidence: high
status: active
---

RoseTTAFold2 is a three-track folding tool, which also handles multimer!
inputs: amino acid sequence + CHEMICAL structure (WOAH! how?) &ldquo;RF2 all-atom embedding&rdquo; fold! The model does really well!
application: de-novo luciferase design come up with the correct shaped scaffolds use old Rosetta to jam a residue sequence into the scaffold refold application: RoseTTAFold2 in-painting Train the model to recover the missing bits of sequence from the overall structure (i.e. training backwards), and
