---
title: "Immunogen Design"
source: https://www.jemoka.com/posts/kbhimmunogen_design/
---

Using a bunch of signals to create a 3d representation of the system
features cyro-EM x-ray tomo glynomics/libidomics genetics studying large-scale viron surface protein behavior using MD &ldquo;we are so biased by what we can see experimentally, so do MD&rdquo;
&ldquo;breathing&rdquo; motion proteins of specific virons &ldquo;breath&rdquo;: oning and closing an entire backbone group; this is not yet quantified in physical modeling when its open, the &ldquo;breathing open&rdquo; motion causes the virus to be vunerable so some antibodies jam into the open position &ldquo;head tilting&rdquo; motion when its tilted, there is an epitope that becomes exposed this is a site that&rsquo;s possible for introduction of what&rsquo;s needed overall architecture use conventional MD discover regions of instability (see above for examples) for possible binding surfaces bam inhibition! maybe at some point run a cyro-EM to experimentally run some
